What is ghrelin mimetic

The diagnosis of adult GH deficiency is often challenging. For a definitive diagnosis to be made, most patients require a GH stimulation test, which currently involves administration of parenteral substances, requires trained personnel and monitored facilities, and can be associated with potentially hazardous effects, such as hypoglycaemia. The researchers determined peak GH levels in 50 patients with adult GH deficiency and 48 control individuals following macimorelin administration and found that the sensitivity and specificity of the ghrelin receptor agonist for the diagnosis of adult GH deficiency was similar to that of previously established GH stimulation tests.

No clinically apparent adverse effects occurred. Garcia, J. Download references. You can also search for this author in PubMed Google Scholar. Reprints and Permissions. Koch, L. Novel ghrelin mimetic is safe and effective as a GH stimulation test. Nat Rev Endocrinol 9, Download citation. Published : 16 April Issue Date : June Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. All end points were assessed at baseline and every 6 months.

Results: Daily administration of MK significantly increased growth hormone and insulin-like growth factor I levels to those of healthy young adults without serious adverse effects. Mean fat-free mass decreased in the placebo group but increased in the MK group change, No significant differences were observed in abdominal visceral fat or total fat mass; however, the average increase in limb fat was greater in the MK group than the placebo group 1.

Body weight increased 0. Fasting blood glucose level increased an average of 0. The most frequent side effects were an increase in appetite that subsided in a few months and transient, mild lower-extremity edema and muscle pain. Low-density lipoprotein cholesterol levels decreased in the MK group relative to baseline values change, Changes in bone mineral density consistent with increased bone remodeling occurred in MK recipients. Increased fat-free mass did not result in changes in strength or function.

Two-year exploratory analyses confirmed the 1-year results. Limitation: Study power duration and participant number was insufficient to evaluate functional end points in healthy elderly persons.